Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Rachel J. Perry, Liang Peng, Natasha A. Barry, Gary W. Cline, Dongyan Zhang, Rebecca L. Cardone, Kitt Falk Petersen, Richard G. Kibbey, Andrew L. Goodman and Gerald I. Shulman ()
Additional contact information
Rachel J. Perry: Yale University School of Medicine
Liang Peng: Yale University School of Medicine
Natasha A. Barry: Yale University School of Medicine
Gary W. Cline: Yale University School of Medicine
Dongyan Zhang: Howard Hughes Medical Institute, Yale University School of Medicine
Rebecca L. Cardone: Yale University School of Medicine
Kitt Falk Petersen: Yale University School of Medicine
Richard G. Kibbey: Yale University School of Medicine
Andrew L. Goodman: Yale University School of Medicine
Gerald I. Shulman: Yale University School of Medicine

Nature, 2016, vol. 534, issue 7606, 213-217

Abstract: Abstract Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient–gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (7)

Downloads: (external link)
https://www.nature.com/articles/nature18309 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature18309

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature18309

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().