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Concerted nucleophilic aromatic substitution with 19F− and 18F−

Constanze N. Neumann, Jacob M. Hooker and Tobias Ritter ()
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Constanze N. Neumann: Harvard University
Jacob M. Hooker: Massachusetts General Hospital
Tobias Ritter: Harvard University

Nature, 2016, vol. 534, issue 7607, 369-373

Abstract: Nucleophilic aromatic substitution (SNAr) is the most commonly used method to generate arenes that contain 18F for use in PET imaging; here, an unusual concerted SNAr reaction is presented that is not limited to electron-poor arenes.

Date: 2016
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DOI: 10.1038/nature17667

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