Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy () and Tannishtha Reya ()
Additional contact information
Raymond G. Fox: University of California San Diego School of Medicine La Jolla
Nikki K. Lytle: University of California San Diego School of Medicine La Jolla
Dawn V. Jaquish: Moores Cancer Center, University of California San Diego School of Medicine
Frederick D. Park: University of California San Diego School of Medicine La Jolla
Takahiro Ito: University of California San Diego School of Medicine La Jolla
Jeevisha Bajaj: University of California San Diego School of Medicine La Jolla
Claire S. Koechlein: University of California San Diego School of Medicine La Jolla
Bryan Zimdahl: University of California San Diego School of Medicine La Jolla
Masato Yano: Keio University School of Medicine
Janel L. Kopp: Sanford Consortium for Regenerative Medicine
Marcie Kritzik: University of California San Diego School of Medicine La Jolla
Jason K. Sicklick: Moores Cancer Center, University of California San Diego School of Medicine
Maike Sander: Sanford Consortium for Regenerative Medicine
Paul M. Grandgenett: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
Michael A. Hollingsworth: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
Shinsuke Shibata: Keio University School of Medicine
Donald Pizzo: University of California San Diego School of Medicine
Mark A. Valasek: University of California San Diego School of Medicine
Roman Sasik: Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine
Miriam Scadeng: University of California San Diego School of Medicine
Hideyuki Okano: Keio University School of Medicine
Youngsoo Kim: Ionis Pharmaceuticals
A. Robert MacLeod: Ionis Pharmaceuticals
Andrew M. Lowy: Moores Cancer Center, University of California San Diego School of Medicine
Tannishtha Reya: University of California San Diego School of Medicine La Jolla

Nature, 2016, vol. 534, issue 7607, 407-411

Abstract: The stem cell determinant Musashi (Msi) is a key mediator of pancreatic cancer progression and therapy resistance.

Date: 2016
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DOI: 10.1038/nature17988

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