Co-repressor CBFA2T2 regulates pluripotency and germline development

Shengjiang Tu, Varun Narendra, Masashi Yamaji, Simon E. Vidal, Luis Alejandro Rojas, Xiaoshi Wang, Sang Yong Kim, Benjamin A. Garcia, Thomas Tuschl, Matthias Stadtfeld and Danny Reinberg ()
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Shengjiang Tu: Howard Hughes Medical Institute, New York University School of Medicine
Varun Narendra: Howard Hughes Medical Institute, New York University School of Medicine
Masashi Yamaji: Howard Hughes Medical Institute, Laboratory for RNA Molecular Biology, The Rockefeller University
Simon E. Vidal: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Luis Alejandro Rojas: Howard Hughes Medical Institute, New York University School of Medicine
Xiaoshi Wang: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Sang Yong Kim: Rodent Genetic Engineering Core, NYU School of Medicine
Benjamin A. Garcia: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Thomas Tuschl: Howard Hughes Medical Institute, Laboratory for RNA Molecular Biology, The Rockefeller University
Matthias Stadtfeld: Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Danny Reinberg: Howard Hughes Medical Institute, New York University School of Medicine

Nature, 2016, vol. 534, issue 7607, 387-390

Abstract: A co-repressor protein, CBFA2T2, oligomerizes to stabilize its binding partner PRDM14 and the pluripotency factor OCT4 on chromatin, thus facilitating the transcriptional landscape underpinning the germline and pluripotent fate.

Date: 2016
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DOI: 10.1038/nature18004

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