Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Louise A. Hyslop, Paul Blakeley, Lyndsey Craven, Jessica Richardson, Norah M. E. Fogarty, Elpida Fragouli, Mahdi Lamb, Sissy E. Wamaitha, Nilendran Prathalingam, Qi Zhang, Hannah O’Keefe, Yuko Takeda, Lucia Arizzi, Samer Alfarawati, Helen A. Tuppen, Laura Irving, Dimitrios Kalleas, Meenakshi Choudhary, Dagan Wells, Alison P. Murdoch, Douglass M. Turnbull, Kathy K. Niakan and Mary Herbert ()
Additional contact information
Louise A. Hyslop: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Paul Blakeley: The Francis Crick Institute, Human Embryo and Stem Cell Laboratory
Lyndsey Craven: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School
Jessica Richardson: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Norah M. E. Fogarty: The Francis Crick Institute, Human Embryo and Stem Cell Laboratory
Elpida Fragouli: Reprogenetics UK, Institute of Reproductive Sciences
Mahdi Lamb: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Sissy E. Wamaitha: The Francis Crick Institute, Human Embryo and Stem Cell Laboratory
Nilendran Prathalingam: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Qi Zhang: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Hannah O’Keefe: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Yuko Takeda: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Lucia Arizzi: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Samer Alfarawati: Reprogenetics UK, Institute of Reproductive Sciences
Helen A. Tuppen: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School
Laura Irving: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Dimitrios Kalleas: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
Meenakshi Choudhary: Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life
Dagan Wells: University of Oxford
Alison P. Murdoch: Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life
Douglass M. Turnbull: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School
Kathy K. Niakan: The Francis Crick Institute, Human Embryo and Stem Cell Laboratory
Mary Herbert: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life

Nature, 2016, vol. 534, issue 7607, 383-386

Abstract: Preclinical evaluation and optimization of mitochondrial replacement therapy reveals that a modified form of pronuclear transfer is likely to give rise to normal pregnancies with a reduced risk of mitochondrial DNA disease, but may need further modification to eradicate the disease in all cases.

Date: 2016
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DOI: 10.1038/nature18303

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