Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

Barbara Treutlein, Qian Yi Lee, J. Gray Camp, Moritz Mall, Winston Koh, Seyed Ali Mohammad Shariati, Sopheak Sim, Norma F. Neff, Jan M. Skotheim, Marius Wernig () and Stephen R. Quake ()
Additional contact information
Barbara Treutlein: Stanford University
Qian Yi Lee: Stanford University
J. Gray Camp: Stanford University School of Medicine
Moritz Mall: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Winston Koh: Stanford University
Seyed Ali Mohammad Shariati: Stanford University
Sopheak Sim: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Norma F. Neff: Stanford University
Jan M. Skotheim: Stanford University
Marius Wernig: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Stephen R. Quake: Stanford University

Nature, 2016, vol. 534, issue 7607, 391-395

Abstract: The transcriptome changes driving the conversion of fibroblasts to neurons at the single-cell level are reported, revealing that early neuronal reprogramming steps are homogenous, driven by the proneural pioneer factor Ascl1; the expression of myogenic genes then has a dampening effect on efficiency, which needs to be counteracted by the neuronal factors Myt1l and Brn2 for more efficient reprogramming.

Date: 2016
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DOI: 10.1038/nature18323

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