Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

Shintaro Iwasaki, Stephen N. Floor and Nicholas T. Ingolia ()
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Shintaro Iwasaki: Center for RNA Systems Biology, University of California
Stephen N. Floor: Center for RNA Systems Biology, University of California
Nicholas T. Ingolia: Center for RNA Systems Biology, University of California

Nature, 2016, vol. 534, issue 7608, 558-561

Abstract: The cancer drug rocaglamide A cements the RNA helicase eIF4A on polypurine sequences and thereby prevents scanning of the 43S subunit along the messenger RNA, highlighting how a drug can act by stabilizing sequence-selective RNA–protein interactions.

Date: 2016
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DOI: 10.1038/nature17978

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