Proteome-wide covalent ligand discovery in native biological systems

Keriann M. Backus (), Bruno E. Correia, Kenneth M. Lum, Stefano Forli, Benjamin D. Horning, Gonzalo E. González-Páez, Sandip Chatterjee, Bryan R. Lanning, John R. Teijaro, Arthur J. Olson, Dennis W. Wolan and Benjamin F. Cravatt ()
Additional contact information
Keriann M. Backus: The Scripps Research Institute. La Jolla
Bruno E. Correia: The Scripps Research Institute. La Jolla
Kenneth M. Lum: The Scripps Research Institute. La Jolla
Stefano Forli: The Scripps Research Institute. La Jolla
Benjamin D. Horning: The Scripps Research Institute. La Jolla
Gonzalo E. González-Páez: The Scripps Research Institute. La Jolla
Sandip Chatterjee: The Scripps Research Institute. La Jolla
Bryan R. Lanning: The Scripps Research Institute. La Jolla
John R. Teijaro: The Scripps Research Institute. La Jolla
Arthur J. Olson: The Scripps Research Institute. La Jolla
Dennis W. Wolan: The Scripps Research Institute. La Jolla
Benjamin F. Cravatt: The Scripps Research Institute. La Jolla

Nature, 2016, vol. 534, issue 7608, 570-574

Abstract: Small molecules are powerful tools for investigating protein function, and can serve as leads for new therapeutics, but most human proteins lack known small-molecule ligands; here, a quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins is reported.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:534:y:2016:i:7608:d:10.1038_nature18002

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DOI: 10.1038/nature18002

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