The bacteriophage ϕ29 tail possesses a pore-forming loop for cell membrane penetration

Jingwei Xu, Miao Gui, Dianhong Wang and Ye Xiang ()
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Jingwei Xu: Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
Miao Gui: Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
Dianhong Wang: Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
Ye Xiang: Centre for Infectious Diseases Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University

Nature, 2016, vol. 534, issue 7608, 544-547

Abstract: Structural and functional studies of the tail knob protein of bacteriophage ϕ29 shed light on how the phage breaches the membrane barrier and ejects its DNA genome into the host cell.

Date: 2016
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DOI: 10.1038/nature18017

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