A complement–microglial axis drives synapse loss during virus-induced memory impairment

Michael J. Vasek, Charise Garber, Denise Dorsey, Douglas M. Durrant, Bryan Bollman, Allison Soung, Jinsheng Yu, Carlos Perez-Torres, Arnaud Frouin, Daniel K. Wilton, Kristen Funk, Bette K. DeMasters, Xiaoping Jiang, James R. Bowen, Steven Mennerick, John K. Robinson, Joel R. Garbow, Kenneth L. Tyler, Mehul S. Suthar, Robert E. Schmidt, Beth Stevens and Robyn S. Klein ()
Additional contact information
Michael J. Vasek: Washington University School of Medicine
Charise Garber: Washington University School of Medicine
Denise Dorsey: Washington University School of Medicine
Douglas M. Durrant: Washington University School of Medicine
Bryan Bollman: Washington University School of Medicine
Allison Soung: Washington University School of Medicine
Jinsheng Yu: Washington University School of Medicine
Carlos Perez-Torres: Washington University School of Medicine
Arnaud Frouin: F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School
Daniel K. Wilton: F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School
Kristen Funk: Washington University School of Medicine
Bette K. DeMasters: University of Colorado School of Medicine
Xiaoping Jiang: Washington University School of Medicine
James R. Bowen: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine
Steven Mennerick: Washington University School of Medicine
John K. Robinson: Stony Brook University
Joel R. Garbow: Washington University School of Medicine
Kenneth L. Tyler: University of Colorado School of Medicine
Mehul S. Suthar: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine
Robert E. Schmidt: Washington University School of Medicine
Beth Stevens: F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School
Robyn S. Klein: Washington University School of Medicine

Nature, 2016, vol. 534, issue 7608, 538-543

Abstract: People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with the virus experience a loss in hippocampal presynaptic terminals, which can be reversed by disrupting complement or microglia in mice.

Date: 2016
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DOI: 10.1038/nature18283

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