Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

Umeharu Ohto (), Hanako Ishida, Elena Krayukhina, Susumu Uchiyama, Naokazu Inoue and Toshiyuki Shimizu ()
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Umeharu Ohto: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo
Hanako Ishida: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo
Elena Krayukhina: Graduate School of Engineering, Osaka University
Susumu Uchiyama: Graduate School of Engineering, Osaka University
Naokazu Inoue: Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University
Toshiyuki Shimizu: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo

Nature, 2016, vol. 534, issue 7608, 566-569

Abstract: The structure of the IZUMO1–JUNO complex, crucial for sperm–oocyte interaction during fertilization, is reported, providing a first step towards understanding the mechanics of the interaction.

Date: 2016
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DOI: 10.1038/nature18596

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