Hemi-fused structure mediates and controls fusion and fission in live cells

Wei-Dong Zhao, Edaeni Hamid, Wonchul Shin, Peter J. Wen, Evan S. Krystofiak, Seth A. Villarreal, Hsueh-Cheng Chiang, Bechara Kachar and Ling-Gang Wu ()
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Wei-Dong Zhao: National Institute of Neurological Disorders and Stroke
Edaeni Hamid: National Institute of Neurological Disorders and Stroke
Wonchul Shin: National Institute of Neurological Disorders and Stroke
Peter J. Wen: National Institute of Neurological Disorders and Stroke
Evan S. Krystofiak: National Institute on Deafness and other Communication Disorders
Seth A. Villarreal: National Institute of Neurological Disorders and Stroke
Hsueh-Cheng Chiang: National Institute of Neurological Disorders and Stroke
Bechara Kachar: National Institute on Deafness and other Communication Disorders
Ling-Gang Wu: National Institute of Neurological Disorders and Stroke

Nature, 2016, vol. 534, issue 7608, 548-552

Abstract: Super-resolution imaging provides direct evidence in live cells that membrane fusion and fission are mediated through an intermediate hemi-fused structure, where fusion and calcium/dynamin-dependent fission mechanisms compete to determine the transition of the intermediate to fusion or fission.

Date: 2016
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DOI: 10.1038/nature18598

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