Translation readthrough mitigation

Joshua A. Arribere, Elif S. Cenik, Nimit Jain, Gaelen T. Hess, Cameron H. Lee, Michael C. Bassik and Andrew Z. Fire ()
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Joshua A. Arribere: Stanford University School of Medicine
Elif S. Cenik: Stanford University School of Medicine
Nimit Jain: Stanford University
Gaelen T. Hess: Stanford University School of Medicine
Cameron H. Lee: Stanford University School of Medicine
Michael C. Bassik: Stanford University School of Medicine
Andrew Z. Fire: Stanford University School of Medicine

Nature, 2016, vol. 534, issue 7609, 719-723

Abstract: Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating through peptides that are encoded within the 3' UTR of genes in both humans and C. elegans.

Date: 2016
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DOI: 10.1038/nature18308

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