H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

Giulia Saredi, Hongda Huang, Colin M. Hammond, Constance Alabert, Simon Bekker-Jensen, Ignasi Forne, Nazaret Reverón-Gómez, Benjamin M. Foster, Lucie Mlejnkova, Till Bartke, Petr Cejka, Niels Mailand, Axel Imhof, Dinshaw J. Patel () and Anja Groth ()
Additional contact information
Giulia Saredi: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen
Hongda Huang: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Colin M. Hammond: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen
Constance Alabert: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen
Simon Bekker-Jensen: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Ignasi Forne: Biomedical Center and Center for Integrated Protein Science Munich, Ludwig-Maximilians University
Nazaret Reverón-Gómez: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen
Benjamin M. Foster: MRC Clinical Sciences Centre (CSC) and Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London
Lucie Mlejnkova: Institute of Molecular Cancer Research, University of Zurich
Till Bartke: MRC Clinical Sciences Centre (CSC) and Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London
Petr Cejka: Institute of Molecular Cancer Research, University of Zurich
Niels Mailand: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Axel Imhof: Biomedical Center and Center for Integrated Protein Science Munich, Ludwig-Maximilians University
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Anja Groth: Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen

Nature, 2016, vol. 534, issue 7609, 714-718

Abstract: We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.

Date: 2016
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DOI: 10.1038/nature18312

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