Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing

Justin Jee, Aviram Rasouly, Ilya Shamovsky, Yonatan Akivis, Susan R. Steinman, Bud Mishra () and Evgeny Nudler ()
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Justin Jee: New York University School of Medicine
Aviram Rasouly: New York University School of Medicine
Ilya Shamovsky: New York University School of Medicine
Yonatan Akivis: New York University School of Medicine
Susan R. Steinman: New York University School of Medicine
Bud Mishra: Courant Institute of Mathematical Sciences, New York University
Evgeny Nudler: New York University School of Medicine

Nature, 2016, vol. 534, issue 7609, 693-696

Abstract: Maximum-depth sequencing (MDS), a new method of detecting extremely rare variants within a bacterial population, is used to show that mutation rates in Escherichia coli vary across the genome by at least an order of magnitude, and also to uncover mechanisms of antibiotic-induced mutagenesis.

Date: 2016
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DOI: 10.1038/nature18313

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