Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis and Andreas J. Bäumler ()
Additional contact information
Franziska Faber: School of Medicine, University of California at Davis, One Shields Avenue
Lisa Tran: School of Medicine, University of California at Davis, One Shields Avenue
Mariana X. Byndloss: School of Medicine, University of California at Davis, One Shields Avenue
Christopher A. Lopez: School of Medicine, University of California at Davis, One Shields Avenue
Eric M. Velazquez: School of Medicine, University of California at Davis, One Shields Avenue
Tobias Kerrinnes: School of Medicine, University of California at Davis, One Shields Avenue
Sean-Paul Nuccio: School of Medicine, University of California at Davis, One Shields Avenue
Tamding Wangdi: School of Medicine, University of California at Davis, One Shields Avenue
Oliver Fiehn: Genome Center, University of California at Davis, One Shields Avenue
Renée M. Tsolis: School of Medicine, University of California at Davis, One Shields Avenue
Andreas J. Bäumler: School of Medicine, University of California at Davis, One Shields Avenue

Nature, 2016, vol. 534, issue 7609, 697-699

Abstract: Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.

Date: 2016
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DOI: 10.1038/nature18597

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