Design of a hyperstable 60-subunit protein icosahedron

Yang Hsia, Jacob B. Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K. Fong, Una Nattermann, Chunfu Xu, Po-Ssu Huang, Rashmi Ravichandran, Sue Yi, Trisha N. Davis, Tamir Gonen, Neil P. King and David Baker ()
Additional contact information
Yang Hsia: University of Washington
Jacob B. Bale: University of Washington
Shane Gonen: University of Washington
Dan Shi: Janelia Research Campus, Howard Hughes Medical Institute
William Sheffler: University of Washington
Kimberly K. Fong: University of Washington
Una Nattermann: University of Washington
Chunfu Xu: University of Washington
Po-Ssu Huang: University of Washington
Rashmi Ravichandran: University of Washington
Sue Yi: University of Washington
Trisha N. Davis: University of Washington
Tamir Gonen: Janelia Research Campus, Howard Hughes Medical Institute
Neil P. King: University of Washington
David Baker: University of Washington

Nature, 2016, vol. 535, issue 7610, 136-139

Abstract: The computational design of an extremely stable icosahedral self-assembling protein nanocage is presented; the icosahedron should be useful for applications ranging from calibrating fluorescence microscopy to drug delivery.

Date: 2016
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DOI: 10.1038/nature18010

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