The nature of mutations induced by replication–transcription collisions

T. Sabari Sankar, Brigitta D. Wastuwidyaningtyas, Yuexin Dong, Sarah A. Lewis and Jue D. Wang ()
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T. Sabari Sankar: University of Wisconsin-Madison
Brigitta D. Wastuwidyaningtyas: Baylor College of Medicine
Yuexin Dong: University of Wisconsin-Madison
Sarah A. Lewis: Baylor College of Medicine
Jue D. Wang: University of Wisconsin-Madison

Nature, 2016, vol. 535, issue 7610, 178-181

Abstract: When transcription and replication machineries collide on DNA, they can cause mutations to occur in the area near the collision; these mutations are now shown to include two types—duplications/deletions within the transcription unit and base substitutions in the cis-regulatory element of gene expression.

Date: 2016
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DOI: 10.1038/nature18316

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