A core viral protein binds host nucleosomes to sequester immune danger signals

Daphne C. Avgousti, Christin Herrmann, Katarzyna Kulej, Neha J. Pancholi, Nikolina Sekulic, Joana Petrescu, Rosalynn C. Molden, Daniel Blumenthal, Andrew J. Paris, Emigdio D. Reyes, Philomena Ostapchuk, Patrick Hearing, Steven H. Seeholzer, G. Scott Worthen, Ben E. Black, Benjamin A. Garcia and Matthew D. Weitzman ()
Additional contact information
Daphne C. Avgousti: University of Pennsylvania Perelman School of Medicine
Christin Herrmann: Children’s Hospital of Philadelphia
Katarzyna Kulej: University of Pennsylvania Perelman School of Medicine
Neha J. Pancholi: Children’s Hospital of Philadelphia
Nikolina Sekulic: University of Pennsylvania Perelman School of Medicine
Joana Petrescu: Children’s Hospital of Philadelphia
Rosalynn C. Molden: Epigenetics Program, University of Pennsylvania Perelman School of Medicine
Daniel Blumenthal: Children’s Hospital of Philadelphia
Andrew J. Paris: Allergy, and Critical Care Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine
Emigdio D. Reyes: University of Pennsylvania Perelman School of Medicine
Philomena Ostapchuk: School of Medicine, Stony Brook University
Patrick Hearing: School of Medicine, Stony Brook University
Steven H. Seeholzer: Protein and Proteomics Core, Children’s Hospital of Philadelphia
G. Scott Worthen: Children’s Hospital of Philadelphia, Philadelphia, University of Pennsylvania Perelman School of Medicine
Ben E. Black: University of Pennsylvania Perelman School of Medicine
Benjamin A. Garcia: University of Pennsylvania Perelman School of Medicine
Matthew D. Weitzman: University of Pennsylvania Perelman School of Medicine

Nature, 2016, vol. 535, issue 7610, 173-177

Abstract: Here, a small core protein of human adenoviruses is shown to associate with histones, sequestering proteins on host chromatin and preventing inflammatory proteins from being released and triggering inflammation.

Date: 2016
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DOI: 10.1038/nature18317

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