A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Rong Zhang, Jonathan J. Miner, Matthew J. Gorman, Keiko Rausch, Holly Ramage, James P. White, Adam Zuiani, Ping Zhang, Estefania Fernandez, Qiang Zhang, Kimberly A. Dowd, Theodore C. Pierson, Sara Cherry and Michael S. Diamond ()
Additional contact information
Rong Zhang: Washington University School of Medicine
Jonathan J. Miner: Washington University School of Medicine
Matthew J. Gorman: Washington University School of Medicine
Keiko Rausch: Perelman School of Medicine, University of Pennsylvania
Holly Ramage: Perelman School of Medicine, University of Pennsylvania
James P. White: Washington University School of Medicine
Adam Zuiani: Washington University School of Medicine
Ping Zhang: Washington University School of Medicine
Estefania Fernandez: Washington University School of Medicine
Qiang Zhang: Washington University School of Medicine
Kimberly A. Dowd: Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Theodore C. Pierson: Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Sara Cherry: Perelman School of Medicine, University of Pennsylvania
Michael S. Diamond: Washington University School of Medicine

Nature, 2016, vol. 535, issue 7610, 164-168

Abstract: Components of the endoplasmic-reticulum-associated signal peptidase complex is required for infection by numerous flaviviruses, including West Nile, dengue and Zika viruses, but is not required for infection by other types of virus or for host protein synthesis.

Date: 2016
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DOI: 10.1038/nature18625

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