Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu () and Judy Lieberman ()
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Xing Liu: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Zhibin Zhang: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Jianbin Ruan: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Youdong Pan: Brigham and Women’s Hospital
Venkat Giri Magupalli: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Hao Wu: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Judy Lieberman: Program in Cellular and Molecular Medicine, Boston Children’s Hospital

Nature, 2016, vol. 535, issue 7610, 153-158

Abstract: Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.

Date: 2016
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DOI: 10.1038/nature18629

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