Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Caleb D. Marceau, Andreas S. Puschnik, Karim Majzoub, Yaw Shin Ooi, Susan M. Brewer, Gabriele Fuchs, Kavya Swaminathan, Miguel A. Mata, Joshua E. Elias, Peter Sarnow and Jan E. Carette ()
Additional contact information
Caleb D. Marceau: Stanford University
Andreas S. Puschnik: Stanford University
Karim Majzoub: Stanford University
Yaw Shin Ooi: Stanford University
Susan M. Brewer: Stanford University
Gabriele Fuchs: Stanford University
Kavya Swaminathan: Stanford University
Miguel A. Mata: Stanford University
Joshua E. Elias: Stanford University
Peter Sarnow: Stanford University
Jan E. Carette: Stanford University

Nature, 2016, vol. 535, issue 7610, 159-163

Abstract: A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

Date: 2016
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DOI: 10.1038/nature18631

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