Diet–microbiota interactions as moderators of human metabolism

Justin L. Sonnenburg () and Fredrik Bäckhed ()
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Justin L. Sonnenburg: Stanford University School of Medicine
Fredrik Bäckhed: Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg

Nature, 2016, vol. 535, issue 7610, 56-64

Abstract: Abstract It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

Date: 2016
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DOI: 10.1038/nature18846

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