Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

Philipp S. Hoppe, Michael Schwarzfischer, Dirk Loeffler, Konstantinos D. Kokkaliaris, Oliver Hilsenbeck, Nadine Moritz, Max Endele, Adam Filipczyk, Adriana Gambardella, Nouraiz Ahmed, Martin Etzrodt, Daniel L. Coutu, Michael A. Rieger, Carsten Marr, Michael K. Strasser, Bernhard Schauberger, Ingo Burtscher, Olga Ermakova, Antje Bürger, Heiko Lickert, Claus Nerlov, Fabian J. Theis and Timm Schroeder ()
Additional contact information
Philipp S. Hoppe: Department of Biosystems Science and Engineering
Michael Schwarzfischer: Institute of Computational Biology, Helmholtz Zentrum München
Dirk Loeffler: Department of Biosystems Science and Engineering
Konstantinos D. Kokkaliaris: Department of Biosystems Science and Engineering
Oliver Hilsenbeck: Department of Biosystems Science and Engineering
Nadine Moritz: Research Unit Stem Cell Dynamics, Helmholtz Zentrum München
Max Endele: Department of Biosystems Science and Engineering
Adam Filipczyk: Research Unit Stem Cell Dynamics, Helmholtz Zentrum München
Adriana Gambardella: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
Nouraiz Ahmed: Department of Biosystems Science and Engineering
Martin Etzrodt: Department of Biosystems Science and Engineering
Daniel L. Coutu: Department of Biosystems Science and Engineering
Michael A. Rieger: Research Unit Stem Cell Dynamics, Helmholtz Zentrum München
Carsten Marr: Institute of Computational Biology, Helmholtz Zentrum München
Michael K. Strasser: Institute of Computational Biology, Helmholtz Zentrum München
Bernhard Schauberger: Research Unit Stem Cell Dynamics, Helmholtz Zentrum München
Ingo Burtscher: Institute of Diabetes and Regeneration Research, Institute of Stem Cell Research, Helmholtz Zentrum München
Olga Ermakova: Istituto di Biologia Cellulare e Neurobiologia, CNR
Antje Bürger: Institute of Developmental Genetics, Helmholtz Zentrum München
Heiko Lickert: Institute of Diabetes and Regeneration Research, Institute of Stem Cell Research, Helmholtz Zentrum München
Claus Nerlov: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
Fabian J. Theis: Institute of Computational Biology, Helmholtz Zentrum München
Timm Schroeder: Department of Biosystems Science and Engineering

Nature, 2016, vol. 535, issue 7611, 299-302

Abstract: Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

Date: 2016
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DOI: 10.1038/nature18320

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