Ki-67 acts as a biological surfactant to disperse mitotic chromosomes

Sara Cuylen, Claudia Blaukopf, Antonio Z. Politi, Thomas Müller-Reichert, Beate Neumann, Ina Poser, Jan Ellenberg, Anthony A. Hyman and Daniel W. Gerlich ()
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Sara Cuylen: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Claudia Blaukopf: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Antonio Z. Politi: Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)
Thomas Müller-Reichert: Medical Faculty Carl Gustav Carus, Experimental Center, Technische Universität Dresden
Beate Neumann: Advanced Light Microscopy Facility, European Molecular Biology Laboratory (EMBL)
Ina Poser: Max Planck Institute of Molecular Cell Biology and Genetics
Jan Ellenberg: Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)
Anthony A. Hyman: Max Planck Institute of Molecular Cell Biology and Genetics
Daniel W. Gerlich: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)

Nature, 2016, vol. 535, issue 7611, 308-312

Abstract: During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has biophysical properties similar to those of surfactants.

Date: 2016
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DOI: 10.1038/nature18610

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