Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

Sven Reischauer, Oliver A. Stone, Alethia Villasenor, Neil Chi, Suk-Won Jin, Marcel Martin, Miler T. Lee, Nana Fukuda, Michele Marass, Alec Witty, Ian Fiddes, Taiyi Kuo, Won-Suk Chung, Sherveen Salek, Robert Lerrigo, Jessica Alsiö, Shujun Luo, Dominika Tworus, Sruthy M. Augustine, Sophie Mucenieks, Björn Nystedt, Antonio J. Giraldez, Gary P. Schroth, Olov Andersson and Didier Y. R. Stainier ()
Additional contact information
Sven Reischauer: University of California San Francisco
Oliver A. Stone: University of California San Francisco
Alethia Villasenor: University of California San Francisco
Neil Chi: University of California San Francisco
Suk-Won Jin: University of California San Francisco
Marcel Martin: Science for Life Laboratory, Stockholm University
Miler T. Lee: Yale University School of Medicine
Nana Fukuda: Max Planck Institute for Heart and Lung Research
Michele Marass: Max Planck Institute for Heart and Lung Research
Alec Witty: Institute of Genomic Medicine, University of California San Diego
Ian Fiddes: University of California San Francisco
Taiyi Kuo: University of California San Francisco
Won-Suk Chung: University of California San Francisco
Sherveen Salek: University of California San Francisco
Robert Lerrigo: University of California San Francisco
Jessica Alsiö: University of California San Francisco
Shujun Luo: Illumina
Dominika Tworus: Karolinska Institutet
Sruthy M. Augustine: Max Planck Institute for Heart and Lung Research
Sophie Mucenieks: Max Planck Institute for Heart and Lung Research
Björn Nystedt: Science for Life Laboratory, Uppsala University
Antonio J. Giraldez: Yale University School of Medicine
Gary P. Schroth: Illumina
Olov Andersson: Karolinska Institutet
Didier Y. R. Stainier: University of California San Francisco

Nature, 2016, vol. 535, issue 7611, 294-298

Abstract: The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature18614 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:535:y:2016:i:7611:d:10.1038_nature18614

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature18614

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().