The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

Jeremy G. Bird, Yu Zhang, Yuan Tian, Natalya Panova, Ivan Barvík, Landon Greene, Min Liu, Brian Buckley, Libor Krásný, Jeehiun K. Lee, Craig D. Kaplan, Richard H. Ebright () and Bryce E. Nickels ()
Additional contact information
Jeremy G. Bird: Rutgers University
Yu Zhang: Rutgers University
Yuan Tian: Rutgers University
Natalya Panova: Institute of Microbiology, Czech Academy of Sciences, v.v.i., Vídenˇ ská 1083
Ivan Barvík: Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague
Landon Greene: Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, One Squibb Drive
Min Liu: Environmental and Occupational Health Sciences Institute, Rutgers University
Brian Buckley: Environmental and Occupational Health Sciences Institute, Rutgers University
Libor Krásný: Institute of Microbiology, Czech Academy of Sciences, v.v.i., Vídenˇ ská 1083
Jeehiun K. Lee: Rutgers University
Craig D. Kaplan: Texas A&M University
Richard H. Ebright: Rutgers University
Bryce E. Nickels: Rutgers University

Nature, 2016, vol. 535, issue 7612, 444-447

Abstract: RNA caps other than the 7-methylguanylate modification are generated by a distinct mechanism in which caps are added during, not after, transcription initiation through the use of non-canonical initiating nucleotides by RNA polymerases, a finding which has functional consequences.

Date: 2016
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DOI: 10.1038/nature18622

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