Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Dean P. Staus, Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, Seungkirl Ahn, Arnab Chatterjee, Ali Masoudi, Andrew C. Kruse, Els Pardon, Jan Steyaert, William I. Weis, R. Scott Prosser, Brian K. Kobilka (), Tommaso Costa () and Robert J. Lefkowitz ()
Additional contact information
Dean P. Staus: Duke University Medical Center
Ryan T. Strachan: University of North Carolina
Aashish Manglik: Stanford University School of Medicine
Biswaranjan Pani: Duke University Medical Center
Alem W. Kahsai: Duke University Medical Center
Tae Hun Kim: University of Toronto, University of Toronto Mississauga
Laura M. Wingler: Duke University Medical Center
Seungkirl Ahn: Duke University Medical Center
Arnab Chatterjee: Duke University Medical Center
Ali Masoudi: Duke University Medical Center
Andrew C. Kruse: Harvard Medical School
Els Pardon: Structural Biology Brussels, Vrije Universiteit Brussel
Jan Steyaert: Structural Biology Brussels, Vrije Universiteit Brussel
William I. Weis: Stanford University School of Medicine
R. Scott Prosser: University of Toronto, University of Toronto Mississauga
Brian K. Kobilka: Stanford University School of Medicine
Tommaso Costa: Istituto Superiore di Sanità
Robert J. Lefkowitz: Duke University Medical Center

Nature, 2016, vol. 535, issue 7612, 448-452

Abstract: Stabilization of an active and inactive conformation of the β2-adrenergic receptor by allosteric nanobodies reveals differential ligand-dependent regulation of receptor states to control G-protein-coupled receptor activation.

Date: 2016
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DOI: 10.1038/nature18636

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