A comprehensive transcriptional map of primate brain development

Bakken, Trygve E.; Miller, Jeremy A.; Ding, Song-Lin; Sunkin, Susan M.; Smith, Kimberly A.; Ng, Lydia; Szafer, Aaron; Dalley, Rachel A.; Royall, Joshua J.; Lemon, Tracy; Shapouri, Sheila; Aiona, Kaylynn; Arnold, James; Bennett, Jeffrey L.; Bertagnolli, Darren; Bickley, Kristopher; Boe, Andrew; Brouner, Krissy; Butler, Stephanie; Byrnes, Emi; Caldejon, Shiella; Carey, Anita; Cate, Shelby; Chapin, Mike; Chen, Jefferey; Dee, Nick; Desta, Tsega; Dolbeare, Tim A.; Dotson, Nadia; Ebbert, Amanda; Fulfs, Erich; Gee, Garrett; Gilbert, Terri L.; Goldy, Jeff; Gourley, Lindsey; Gregor, Ben; Gu, Guangyu; Hall, Jon; Haradon, Zeb; Haynor, David R.; Hejazinia, Nika; Hoerder-Suabedissen, Anna; Howard, Robert; Jochim, Jay; Kinnunen, Marty; Kriedberg, Ali; Kuan, Chihchau L.; Lau, Christopher; Lee, Chang-Kyu; Lee, Felix; Luong, Lon; Mastan, Naveed; May, Ryan; Melchor, Jose; Mosqueda, Nerick; Mott, Erika; Ngo, Kiet; Nyhus, Julie; Oldre, Aaron; Olson, Eric; Parente, Jody; Parker, Patrick D.; Parry, Sheana; Pendergraft, Julie; Potekhina, Lydia; Reding, Melissa; Riley, Zackery L.; Roberts, Tyson; Rogers, Brandon; Roll, Kate; Rosen, David; Sandman, David; Sarreal, Melaine; Shapovalova, Nadiya; Shi, Shu; Sjoquist, Nathan; Sodt, Andy J.; Townsend, Robbie; Velasquez, Lissette; Wagley, Udi; Wakeman, Wayne B.; White, Cassandra; Bennett, Crissa; Wu, Jennifer; Young, Rob; Youngstrom, Brian L.; Wohnoutka, Paul; Gibbs, Richard A.; Rogers, Jeffrey; Hohmann, John G.; Hawrylycz, Michael J.; Hevner, Robert F.; Molnár, Zoltán; Phillips, John W.; Dang, Chinh; Jones, Allan R.; Amaral, David G.; Bernard, Amy; Lein, Ed S.

A comprehensive transcriptional map of primate brain development

Trygve E. Bakken, Jeremy A. Miller, Song-Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng, Aaron Szafer, Rachel A. Dalley, Joshua J. Royall, Tracy Lemon, Sheila Shapouri, Kaylynn Aiona, James Arnold, Jeffrey L. Bennett, Darren Bertagnolli, Kristopher Bickley, Andrew Boe, Krissy Brouner, Stephanie Butler, Emi Byrnes, Shiella Caldejon, Anita Carey, Shelby Cate, Mike Chapin, Jefferey Chen, Nick Dee, Tsega Desta, Tim A. Dolbeare, Nadia Dotson, Amanda Ebbert, Erich Fulfs, Garrett Gee, Terri L. Gilbert, Jeff Goldy, Lindsey Gourley, Ben Gregor, Guangyu Gu, Jon Hall, Zeb Haradon, David R. Haynor, Nika Hejazinia, Anna Hoerder-Suabedissen, Robert Howard, Jay Jochim, Marty Kinnunen, Ali Kriedberg, Chihchau L. Kuan, Christopher Lau, Chang-Kyu Lee, Felix Lee, Lon Luong, Naveed Mastan, Ryan May, Jose Melchor, Nerick Mosqueda, Erika Mott, Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D. Parker, Sheana Parry, Julie Pendergraft, Lydia Potekhina, Melissa Reding, Zackery L. Riley, Tyson Roberts, Brandon Rogers, Kate Roll, David Rosen, David Sandman, Melaine Sarreal, Nadiya Shapovalova, Shu Shi, Nathan Sjoquist, Andy J. Sodt, Robbie Townsend, Lissette Velasquez, Udi Wagley, Wayne B. Wakeman, Cassandra White, Crissa Bennett, Jennifer Wu, Rob Young, Brian L. Youngstrom, Paul Wohnoutka, Richard A. Gibbs, Jeffrey Rogers, John G. Hohmann, Michael J. Hawrylycz, Robert F. Hevner, Zoltán Molnár, John W. Phillips, Chinh Dang, Allan R. Jones, David G. Amaral, Amy Bernard and Ed S. Lein ()
Additional contact information
Trygve E. Bakken: Allen Institute for Brain Science
Jeremy A. Miller: Allen Institute for Brain Science
Song-Lin Ding: Allen Institute for Brain Science
Susan M. Sunkin: Allen Institute for Brain Science
Kimberly A. Smith: Allen Institute for Brain Science
Lydia Ng: Allen Institute for Brain Science
Aaron Szafer: Allen Institute for Brain Science
Rachel A. Dalley: Allen Institute for Brain Science
Joshua J. Royall: Allen Institute for Brain Science
Tracy Lemon: Allen Institute for Brain Science
Sheila Shapouri: Allen Institute for Brain Science
Kaylynn Aiona: Allen Institute for Brain Science
James Arnold: Allen Institute for Brain Science
Jeffrey L. Bennett: California National Primate Research Center, The M.I.N.D. Institute, University of California, Davis
Darren Bertagnolli: Allen Institute for Brain Science
Kristopher Bickley: Allen Institute for Brain Science
Andrew Boe: Allen Institute for Brain Science
Krissy Brouner: Allen Institute for Brain Science
Stephanie Butler: Allen Institute for Brain Science
Emi Byrnes: Allen Institute for Brain Science
Shiella Caldejon: Allen Institute for Brain Science
Anita Carey: Allen Institute for Brain Science
Shelby Cate: Allen Institute for Brain Science
Mike Chapin: Allen Institute for Brain Science
Jefferey Chen: Allen Institute for Brain Science
Nick Dee: Allen Institute for Brain Science
Tsega Desta: Allen Institute for Brain Science
Tim A. Dolbeare: Allen Institute for Brain Science
Nadia Dotson: Allen Institute for Brain Science
Amanda Ebbert: Allen Institute for Brain Science
Erich Fulfs: Allen Institute for Brain Science
Garrett Gee: Allen Institute for Brain Science
Terri L. Gilbert: Allen Institute for Brain Science
Jeff Goldy: Allen Institute for Brain Science
Lindsey Gourley: Allen Institute for Brain Science
Ben Gregor: Allen Institute for Brain Science
Guangyu Gu: Allen Institute for Brain Science
Jon Hall: Allen Institute for Brain Science
Zeb Haradon: Allen Institute for Brain Science
David R. Haynor: University of Washington, Seattle
Nika Hejazinia: Allen Institute for Brain Science
Anna Hoerder-Suabedissen: Anatomy and Genetics, University of Oxford
Robert Howard: Allen Institute for Brain Science
Jay Jochim: Allen Institute for Brain Science
Marty Kinnunen: Allen Institute for Brain Science
Ali Kriedberg: Allen Institute for Brain Science
Chihchau L. Kuan: Allen Institute for Brain Science
Christopher Lau: Allen Institute for Brain Science
Chang-Kyu Lee: Allen Institute for Brain Science
Felix Lee: Allen Institute for Brain Science
Lon Luong: Allen Institute for Brain Science
Naveed Mastan: Allen Institute for Brain Science
Ryan May: Allen Institute for Brain Science
Jose Melchor: Allen Institute for Brain Science
Nerick Mosqueda: Allen Institute for Brain Science
Erika Mott: Allen Institute for Brain Science
Kiet Ngo: Allen Institute for Brain Science
Julie Nyhus: Allen Institute for Brain Science
Aaron Oldre: Allen Institute for Brain Science
Eric Olson: Allen Institute for Brain Science
Jody Parente: Allen Institute for Brain Science
Patrick D. Parker: Allen Institute for Brain Science
Sheana Parry: Allen Institute for Brain Science
Julie Pendergraft: Allen Institute for Brain Science
Lydia Potekhina: Allen Institute for Brain Science
Melissa Reding: Allen Institute for Brain Science
Zackery L. Riley: Allen Institute for Brain Science
Tyson Roberts: Allen Institute for Brain Science
Brandon Rogers: Allen Institute for Brain Science
Kate Roll: Allen Institute for Brain Science
David Rosen: Allen Institute for Brain Science
David Sandman: Allen Institute for Brain Science
Melaine Sarreal: Allen Institute for Brain Science
Nadiya Shapovalova: Allen Institute for Brain Science
Shu Shi: Allen Institute for Brain Science
Nathan Sjoquist: Allen Institute for Brain Science
Andy J. Sodt: Allen Institute for Brain Science
Robbie Townsend: Allen Institute for Brain Science
Lissette Velasquez: Allen Institute for Brain Science
Udi Wagley: Allen Institute for Brain Science
Wayne B. Wakeman: Allen Institute for Brain Science
Cassandra White: Allen Institute for Brain Science
Crissa Bennett: Allen Institute for Brain Science
Jennifer Wu: Allen Institute for Brain Science
Rob Young: Allen Institute for Brain Science
Brian L. Youngstrom: Allen Institute for Brain Science
Paul Wohnoutka: Allen Institute for Brain Science
Richard A. Gibbs: Baylor College of Medicine
Jeffrey Rogers: Baylor College of Medicine
John G. Hohmann: Allen Institute for Brain Science
Michael J. Hawrylycz: Allen Institute for Brain Science
Robert F. Hevner: Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle
Zoltán Molnár: Anatomy and Genetics, University of Oxford
John W. Phillips: Allen Institute for Brain Science
Chinh Dang: Allen Institute for Brain Science
Allan R. Jones: Allen Institute for Brain Science
David G. Amaral: California National Primate Research Center, The M.I.N.D. Institute, University of California, Davis
Amy Bernard: Allen Institute for Brain Science
Ed S. Lein: Allen Institute for Brain Science

Nature, 2016, vol. 535, issue 7612, 367-375

Abstract: Abstract The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.

Date: 2016
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Citations: View citations in EconPapers (12)

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DOI: 10.1038/nature18637

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