Human gut microbes impact host serum metabolome and insulin sensitivity

Helle Krogh Pedersen, Valborg Gudmundsdottir, Henrik Bjørn Nielsen, Tuulia Hyotylainen, Trine Nielsen, Benjamin A. H. Jensen, Kristoffer Forslund, Falk Hildebrand, Edi Prifti, Gwen Falony, Emmanuelle Le Chatelier, Florence Levenez, Joel Doré, Ismo Mattila, Damian R. Plichta, Päivi Pöhö, Lars I. Hellgren, Manimozhiyan Arumugam, Shinichi Sunagawa, Sara Vieira-Silva, Torben Jørgensen, Jacob Bak Holm, Kajetan Trošt, MetaHIT Consortium, Karsten Kristiansen, Susanne Brix, Jeroen Raes, Jun Wang, Torben Hansen, Peer Bork, Søren Brunak (), Matej Oresic (), S. Dusko Ehrlich () and Oluf Pedersen ()
Additional contact information
Helle Krogh Pedersen: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Valborg Gudmundsdottir: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Henrik Bjørn Nielsen: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Tuulia Hyotylainen: University of Örebro
Trine Nielsen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Benjamin A. H. Jensen: Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
Kristoffer Forslund: European Molecular Biology Laboratory
Falk Hildebrand: European Molecular Biology Laboratory
Edi Prifti: MGP MetaGénoPolis, INRA, Université Paris-Saclay
Gwen Falony: Center for the Biology of Disease, VIB
Emmanuelle Le Chatelier: MGP MetaGénoPolis, INRA, Université Paris-Saclay
Florence Levenez: MGP MetaGénoPolis, INRA, Université Paris-Saclay
Joel Doré: MGP MetaGénoPolis, INRA, Université Paris-Saclay
Ismo Mattila: VTT Technical Research Centre of Finland
Damian R. Plichta: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Päivi Pöhö: VTT Technical Research Centre of Finland
Lars I. Hellgren: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Manimozhiyan Arumugam: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Shinichi Sunagawa: European Molecular Biology Laboratory
Sara Vieira-Silva: Center for the Biology of Disease, VIB
Torben Jørgensen: Faculty of Health and Medical Sciences, University of Copenhagen
Jacob Bak Holm: Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
Kajetan Trošt: Steno Diabetes Center
Karsten Kristiansen: Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
Susanne Brix: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Jeroen Raes: Vrije Universiteit Brussel
Jun Wang: Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Peer Bork: European Molecular Biology Laboratory
Søren Brunak: Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
Matej Oresic: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University
S. Dusko Ehrlich: MGP MetaGénoPolis, INRA, Université Paris-Saclay
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

Nature, 2016, vol. 535, issue 7612, 376-381

Abstract: Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

Date: 2016
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DOI: 10.1038/nature18646

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