Structural organization of the inactive X chromosome in the mouse

Luca Giorgetti, Bryan R. Lajoie, Ava C. Carter, Mikael Attia, Ye Zhan, Jin Xu, Chong Jian Chen, Noam Kaplan, Howard Y. Chang, Edith Heard () and Job Dekker ()
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Luca Giorgetti: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
Bryan R. Lajoie: Program in Systems Biology, University of Massachusetts Medical School
Ava C. Carter: Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine
Mikael Attia: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
Ye Zhan: Program in Systems Biology, University of Massachusetts Medical School
Jin Xu: Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine
Chong Jian Chen: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
Noam Kaplan: Program in Systems Biology, University of Massachusetts Medical School
Howard Y. Chang: Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine
Edith Heard: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
Job Dekker: Program in Systems Biology, University of Massachusetts Medical School

Nature, 2016, vol. 535, issue 7613, 575-579

Abstract: An in-depth analysis of the structure, chromatin accessibility and expression status of the mouse inactive X (Xi) chromosome provides insights into the regulation of Xi chromosome structure, its dependence on the macrosatellite DXZ4 region, the Xist non-coding RNA, as well as the basis for topologically associating domain (TAD) formation on the Xi.

Date: 2016
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DOI: 10.1038/nature18589

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