Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fátima Sánchez-Cabo, Carlos Torroja, Rebeca Acín-Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan, María Luisa Bernad-Miana, Eduardo Romanos, Raquel Cruz, Sara Cogliati, Beatriz Sobrino, Ángel Carracedo, Acisclo Pérez-Martos, Patricio Fernández-Silva, Jesús Ruíz-Cabello, Michael P. Murphy, Ignacio Flores, Jesús Vázquez and José Antonio Enríquez ()
Additional contact information
Ana Latorre-Pellicer: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Raquel Moreno-Loshuertos: Universidad de Zaragoza
Ana Victoria Lechuga-Vieco: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Fátima Sánchez-Cabo: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Carlos Torroja: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Rebeca Acín-Pérez: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Enrique Calvo: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Esther Aix: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Andrés González-Guerra: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Angela Logan: Medical Research Council Mitochondrial Biology Unit
María Luisa Bernad-Miana: SAI de Biomedicina y Biomateriales & Phenotypic Unit, Instituto Aragonés de Ciencias de la salud
Eduardo Romanos: SAI de Biomedicina y Biomateriales & Phenotypic Unit, Instituto Aragonés de Ciencias de la salud
Raquel Cruz: Grupo de Medicina Xenómica, CIBERER, Universidad de Santiago de Compostela
Sara Cogliati: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Beatriz Sobrino: Fundación Pública Gallega Medicina Xenómica, SERGAS, Complexo Hospitalario Universitario de Santiago
Ángel Carracedo: Grupo de Medicina Xenómica, CIBERER, Universidad de Santiago de Compostela
Acisclo Pérez-Martos: Universidad de Zaragoza
Patricio Fernández-Silva: Universidad de Zaragoza
Jesús Ruíz-Cabello: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Michael P. Murphy: Medical Research Council Mitochondrial Biology Unit
Ignacio Flores: Centro Nacional de Investigaciones Cardiovasculares Carlos III
Jesús Vázquez: Centro Nacional de Investigaciones Cardiovasculares Carlos III
José Antonio Enríquez: Centro Nacional de Investigaciones Cardiovasculares Carlos III

Nature, 2016, vol. 535, issue 7613, 561-565

Abstract: Conplastic mice that share the same nuclear genome but have different mitochondrial DNA were analysed throughout their life — the mitochondrial genome affects many aspects of physiology and results in differences in median lifespan; the authors propose that the interplay of mitochondrial and nuclear genomes may be an important factor influencing this phenomenon.

Date: 2016
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DOI: 10.1038/nature18618

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