Human commensals producing a novel antibiotic impair pathogen colonization

Alexander Zipperer, Martin C. Konnerth, Claudia Laux, Anne Berscheid, Daniela Janek, Christopher Weidenmaier, Marc Burian, Nadine A. Schilling, Christoph Slavetinsky, Matthias Marschal, Matthias Willmann, Hubert Kalbacher, Birgit Schittek, Heike Brötz-Oesterhelt, Stephanie Grond, Andreas Peschel () and Bernhard Krismer
Additional contact information
Alexander Zipperer: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Martin C. Konnerth: Institute of Organic Chemistry, University of Tübingen
Claudia Laux: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Anne Berscheid: Interfaculty Institute of Microbiology and Infection Medicine, Microbial Bioactive Compounds, University of Tübingen
Daniela Janek: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Christopher Weidenmaier: German Centre for Infection Research (DZIF), Partner Site Tübingen
Marc Burian: University of Tübingen
Nadine A. Schilling: Institute of Organic Chemistry, University of Tübingen
Christoph Slavetinsky: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Matthias Marschal: Interfaculty Institute of Microbiology and Infection Medicine, Medical Microbiology, University of Tübingen
Matthias Willmann: German Centre for Infection Research (DZIF), Partner Site Tübingen
Hubert Kalbacher: Interfaculty Institute of Biochemistry, University of Tübingen
Birgit Schittek: University of Tübingen
Heike Brötz-Oesterhelt: German Centre for Infection Research (DZIF), Partner Site Tübingen
Stephanie Grond: Institute of Organic Chemistry, University of Tübingen
Andreas Peschel: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Bernhard Krismer: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen

Nature, 2016, vol. 535, issue 7613, 511-516

Abstract: The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly reduced S. aureus carriage rate in humans, suggesting that human commensal bacteria could be a valuable resource for the discovery of new antibiotics.

Date: 2016
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DOI: 10.1038/nature18634

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