Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Ineke Brouwer, Gerrit Sitters, Andrea Candelli, Stephanie J. Heerema, Iddo Heller, Abinadabe J. Melo de, Hongshan Zhang, Davide Normanno, Mauro Modesti (), Erwin J. G. Peterman and Gijs J. L. Wuite ()
Additional contact information
Ineke Brouwer: Vrije Universiteit Amsterdam
Gerrit Sitters: Vrije Universiteit Amsterdam
Andrea Candelli: Vrije Universiteit Amsterdam
Stephanie J. Heerema: Vrije Universiteit Amsterdam
Iddo Heller: Vrije Universiteit Amsterdam
Abinadabe J. Melo de: Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105
Hongshan Zhang: Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105
Davide Normanno: Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105
Mauro Modesti: Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105
Erwin J. G. Peterman: Vrije Universiteit Amsterdam
Gijs J. L. Wuite: Vrije Universiteit Amsterdam

Nature, 2016, vol. 535, issue 7613, 566-569

Abstract: A combination of single-molecule techniques shows that the repair proteins XRCC4 and XLF form heteromeric mobile sleeve-like complexes that can bridge and hold together fragments of broken DNA.

Date: 2016
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DOI: 10.1038/nature18643

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