Transfer of mitochondria from astrocytes to neurons after stroke
Kazuhide Hayakawa (),
Elga Esposito,
Xiaohua Wang,
Yasukazu Terasaki,
Yi Liu,
Changhong Xing,
Xunming Ji () and
Eng H. Lo ()
Additional contact information
Kazuhide Hayakawa: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Elga Esposito: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Xiaohua Wang: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Yasukazu Terasaki: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Yi Liu: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Changhong Xing: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Xunming Ji: Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University
Eng H. Lo: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Nature, 2016, vol. 535, issue 7613, 551-555
Abstract:
In a mouse model of ischaemia, mitochondrial particles released from astroctyes are taken up by adjacent neurons, leading to enhanced cell survival signalling; disruption of this release mechanism resulted in worsened neurological outcomes.
Date: 2016
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DOI: 10.1038/nature18928
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