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Transfer of mitochondria from astrocytes to neurons after stroke

Kazuhide Hayakawa (), Elga Esposito, Xiaohua Wang, Yasukazu Terasaki, Yi Liu, Changhong Xing, Xunming Ji () and Eng H. Lo ()
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Kazuhide Hayakawa: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Elga Esposito: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Xiaohua Wang: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Yasukazu Terasaki: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Yi Liu: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Changhong Xing: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
Xunming Ji: Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University
Eng H. Lo: Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School

Nature, 2016, vol. 535, issue 7613, 551-555

Abstract: In a mouse model of ischaemia, mitochondrial particles released from astroctyes are taken up by adjacent neurons, leading to enhanced cell survival signalling; disruption of this release mechanism resulted in worsened neurological outcomes.

Date: 2016
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DOI: 10.1038/nature18928

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