HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Johannes F. Scheid, Joshua A. Horwitz, Yotam Bar-On, Edward F. Kreider, Ching-Lan Lu, Julio C. C. Lorenzi, Anna Feldmann, Malte Braunschweig, Lilian Nogueira, Thiago Oliveira, Irina Shimeliovich, Roshni Patel, Leah Burke, Yehuda Z. Cohen, Sonya Hadrigan, Allison Settler, Maggi Witmer-Pack, Anthony P. West, Jr., Boris Juelg, Tibor Keler, Thomas Hawthorne, Barry Zingman, Roy M. Gulick, Nico Pfeifer, Gerald H. Learn, Michael S. Seaman, Pamela J. Bjorkman, Florian Klein, Sarah J. Schlesinger, Bruce D. Walker, Beatrice H. Hahn, Michel C. Nussenzweig () and Marina Caskey ()
Additional contact information
Johannes F. Scheid: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Joshua A. Horwitz: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Yotam Bar-On: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Edward F. Kreider: Perelman School of Medicine, University of Pennsylvania
Ching-Lan Lu: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Julio C. C. Lorenzi: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Anna Feldmann: Max Planck Institute for Informatics
Malte Braunschweig: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Lilian Nogueira: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Thiago Oliveira: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Irina Shimeliovich: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Roshni Patel: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Leah Burke: Weill Medical College of Cornell University
Yehuda Z. Cohen: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Sonya Hadrigan: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Allison Settler: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Maggi Witmer-Pack: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Anthony P. West, Jr.: California Institute of Technology
Boris Juelg: Ragon Institute of MGH, MIT and Harvard
Tibor Keler: Celldex Therapeutics, Inc.
Thomas Hawthorne: Celldex Therapeutics, Inc.
Barry Zingman: Montefiore Medical Center, Albert Einstein College of Medicine
Roy M. Gulick: Weill Medical College of Cornell University
Nico Pfeifer: Max Planck Institute for Informatics
Gerald H. Learn: Perelman School of Medicine, University of Pennsylvania
Michael S. Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Pamela J. Bjorkman: California Institute of Technology
Florian Klein: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Sarah J. Schlesinger: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard
Beatrice H. Hahn: Perelman School of Medicine, University of Pennsylvania
Michel C. Nussenzweig: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University
Marina Caskey: Laboratory of Molecular Immunology, and 14 Howard Hughes Medical Institute, The Rockefeller University

Nature, 2016, vol. 535, issue 7613, 556-560

Abstract: A phase IIa clinical trial shows that the administration of the broadly neutralizing antibody 3BNC117 delays viral rebound following the discontinuation of antiretroviral therapy in patients who were chronically infected with HIV-1.

Date: 2016
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DOI: 10.1038/nature18929

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