A somitic contribution to the apical ectodermal ridge is essential for fin formation

Wouter Masselink, Nicholas J. Cole, Fruzsina Fenyes, Silke Berger, Carmen Sonntag, Alasdair Wood, Phong D. Nguyen, Naomi Cohen, Franziska Knopf, Gilbert Weidinger, Thomas E. Hall and Peter D. Currie ()
Additional contact information
Wouter Masselink: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Nicholas J. Cole: MND and Neurodegenerative Diseases Research Program, Faculty of Medicine and Heath Science, Macquarie University
Fruzsina Fenyes: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Silke Berger: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Carmen Sonntag: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Alasdair Wood: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Phong D. Nguyen: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Naomi Cohen: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Franziska Knopf: The Kennedy Institute of Rheumatology, University of Oxford
Gilbert Weidinger: Institute of Biochemistry and Molecular Biology, Ulm University
Thomas E. Hall: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University
Peter D. Currie: Australian Regenerative Medicine Institute, Level 1, 15 Innovation Walk, Monash University

Nature, 2016, vol. 535, issue 7613, 542-546

Abstract: Invasion of a somite-derived cell population into the apical ectodermal ridge in zebrafish regulates apical fold induction during fin formation; ablation of these cells inhibits formation of the apical fold and increases the size of the underlying fin bud mesenchyme, suggesting that somite-derived cells play a key part in the evolutionary transition from fins to limbs.

Date: 2016
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DOI: 10.1038/nature18953

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