Synchronized cycles of bacterial lysis for in vivo delivery

M. Omar Din, Tal Danino, Arthur Prindle, Matt Skalak, Jangir Selimkhanov, Kaitlin Allen, Ellixis Julio, Eta Atolia, Lev S. Tsimring, Sangeeta N. Bhatia and Jeff Hasty ()
Additional contact information
M. Omar Din: University of California
Tal Danino: Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Arthur Prindle: University of California
Matt Skalak: Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Jangir Selimkhanov: University of California
Kaitlin Allen: Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Ellixis Julio: University of California
Eta Atolia: Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Lev S. Tsimring: BioCircuits Institute, University of California, San Diego
Sangeeta N. Bhatia: Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Jeff Hasty: University of California

Nature, 2016, vol. 536, issue 7614, 81-85

Abstract: Clinically relevant bacteria have been engineered to lyse synchronously at a threshold population density and release genetically encoded therapeutics; treatment of mice with these bacteria slowed the growth of tumours.

Date: 2016
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Citations: View citations in EconPapers (12)

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DOI: 10.1038/nature18930

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