CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Yoko Kojima, Jens-Peter Volkmer, Kelly McKenna, Mete Civelek, Aldons Jake Lusis, Clint L. Miller, Daniel Direnzo, Vivek Nanda, Jianqin Ye, Andrew J. Connolly, Eric E. Schadt, Thomas Quertermous, Paola Betancur, Lars Maegdefessel, Ljubica Perisic Matic, Ulf Hedin, Irving L. Weissman and Nicholas J. Leeper ()
Additional contact information
Yoko Kojima: Stanford University School of Medicine
Jens-Peter Volkmer: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Kelly McKenna: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Mete Civelek: David Geffen School of Medicine, University of California, Los Angeles
Aldons Jake Lusis: David Geffen School of Medicine, University of California, Los Angeles
Clint L. Miller: Stanford University School of Medicine
Daniel Direnzo: Stanford University School of Medicine
Vivek Nanda: Stanford University School of Medicine
Jianqin Ye: Stanford University School of Medicine
Andrew J. Connolly: Stanford University School of Medicine
Eric E. Schadt: Mount Sinai School of Medicine
Thomas Quertermous: Stanford University School of Medicine
Paola Betancur: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Lars Maegdefessel: Karolinska Institute
Ljubica Perisic Matic: Karolinska Institute
Ulf Hedin: Karolinska Institute
Irving L. Weissman: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Nicholas J. Leeper: Stanford University School of Medicine

Nature, 2016, vol. 536, issue 7614, 86-90

Abstract: Atherosclerotic lesions in mice and humans switch on a ‘don’t eat me’ signal—expression of CD47—that prevents effective removal of diseased tissue; anti-CD47 antibody therapy can normalize this defective efferocytosis, with beneficial results in several mouse models of atherosclerosis.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature18935 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18935

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature18935

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().