Neoantigen landscape dynamics during human melanoma–T cell interactions

Els M. E. Verdegaal (), Noel F. C. C. de Miranda, Marten Visser, Tom Harryvan, Marit M. van Buuren, Rikke S. Andersen, Sine R. Hadrup, Caroline E. van der Minne, Remko Schotte, Hergen Spits, John B. A. G. Haanen, Ellen H. W. Kapiteijn, Ton N. Schumacher and Sjoerd H. van der Burg
Additional contact information
Els M. E. Verdegaal: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Noel F. C. C. de Miranda: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Marten Visser: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Tom Harryvan: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Marit M. van Buuren: Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Rikke S. Andersen: Center for Cancer Immune Therapy, University Hospital Herlev
Sine R. Hadrup: Center for Cancer Immune Therapy, University Hospital Herlev
Caroline E. van der Minne: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Remko Schotte: AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands
Hergen Spits: AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands
John B. A. G. Haanen: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Ellen H. W. Kapiteijn: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Ton N. Schumacher: Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Sjoerd H. van der Burg: Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Nature, 2016, vol. 536, issue 7614, 91-95

Abstract: Analyses of tumour samples and tumour-infiltrating lymphocytes from two patients with melanoma who were treated with adoptive T-cell therapy provide evidence for tumour escape by loss and downregulation of immunogenic antigens.

Date: 2016
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DOI: 10.1038/nature18945

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