eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

Amy S. Y. Lee, Philip J. Kranzusch, Jennifer A. Doudna and Jamie H. D. Cate ()
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Amy S. Y. Lee: University of California, Berkeley
Philip J. Kranzusch: University of California, Berkeley
Jennifer A. Doudna: University of California, Berkeley
Jamie H. D. Cate: University of California, Berkeley

Nature, 2016, vol. 536, issue 7614, 96-99

Abstract: The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d cap-binding domain can be modelled onto the cap structure, defining interactions that are needed for translation of these mRNAs.

Date: 2016
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DOI: 10.1038/nature18954

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