Structure of the adenosine A2A receptor bound to an engineered G protein
Byron Carpenter (),
Rony Nehmé,
Tony Warne,
Andrew G. W. Leslie and
Christopher G. Tate ()
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Byron Carpenter: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Rony Nehmé: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Tony Warne: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Andrew G. W. Leslie: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Christopher G. Tate: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Nature, 2016, vol. 536, issue 7614, 104-107
Abstract:
An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A2A receptor, enabling the acquisition of an X-ray crystal structure of this GPCR in an active state.
Date: 2016
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DOI: 10.1038/nature18966
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