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Structure of the adenosine A2A receptor bound to an engineered G protein

Byron Carpenter (), Rony Nehmé, Tony Warne, Andrew G. W. Leslie and Christopher G. Tate ()
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Byron Carpenter: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Rony Nehmé: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Tony Warne: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Andrew G. W. Leslie: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Christopher G. Tate: MRC Laboratory of Molecular Biology, Francis Crick Avenue

Nature, 2016, vol. 536, issue 7614, 104-107

Abstract: An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A2A receptor, enabling the acquisition of an X-ray crystal structure of this GPCR in an active state.

Date: 2016
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DOI: 10.1038/nature18966

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