An evolutionarily conserved pathway controls proteasome homeostasis

Adrien Rousseau and Anne Bertolotti ()
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Adrien Rousseau: MRC Laboratory of Molecular Biology
Anne Bertolotti: MRC Laboratory of Molecular Biology

Nature, 2016, vol. 536, issue 7615, 184-189

Abstract: Proteasome abundance is crucial for cell survival, but how cells maintain adequate amounts of proteasome is unclear; an analysis in yeast identifies TORC1 and Mpk1 as central components of a pathway regulating proteasome homeostasis through the coordinated regulation of regulatory particle assembly chaperones and proteasome subunits—this pathway is evolutionarily conserved with mTOR and ERK5 regulating proteasome abundance in mammals.

Date: 2016
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DOI: 10.1038/nature18943

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