A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

Ai-Hui Tang (), Haiwen Chen, Tuo P. Li, Sarah R. Metzbower, Harold D. MacGillavry and Thomas A. Blanpied ()
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Ai-Hui Tang: University of Maryland School of Medicine
Haiwen Chen: University of Maryland School of Medicine
Tuo P. Li: University of Maryland School of Medicine
Sarah R. Metzbower: University of Maryland School of Medicine
Harold D. MacGillavry: Cell Biology, Faculty of Science, Utrecht University
Thomas A. Blanpied: University of Maryland School of Medicine

Nature, 2016, vol. 536, issue 7615, 210-214

Abstract: Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.

Date: 2016
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DOI: 10.1038/nature19058

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