Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Robert A. Saxton, Lynne Chantranupong, Kevin E. Knockenhauer, Thomas U. Schwartz () and David M. Sabatini ()
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Robert A. Saxton: Massachusetts Institute of Technology
Lynne Chantranupong: Massachusetts Institute of Technology
Kevin E. Knockenhauer: Massachusetts Institute of Technology
Thomas U. Schwartz: Massachusetts Institute of Technology
David M. Sabatini: Massachusetts Institute of Technology

Nature, 2016, vol. 536, issue 7615, 229-233

Abstract: Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.

Date: 2016
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DOI: 10.1038/nature19079

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