HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

David A. Jacques, William A. McEwan, Laura Hilditch, Amanda J. Price, Greg J. Towers () and Leo C. James ()
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David A. Jacques: MRC Laboratory of Molecular Biology, Francis Crick Avenue
William A. McEwan: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Laura Hilditch: Infection and Immunity, University College London
Amanda J. Price: MRC Laboratory of Molecular Biology, Francis Crick Avenue
Greg J. Towers: Infection and Immunity, University College London
Leo C. James: MRC Laboratory of Molecular Biology, Francis Crick Avenue

Nature, 2016, vol. 536, issue 7616, 349-353

Abstract: Size-selective pores in the HIV-1 capsid hexamer recruit nucleotides, thereby allowing reverse transcription to take place inside the capsid.

Date: 2016
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DOI: 10.1038/nature19098

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