Molecular modifiers reveal a mechanism of pathological crystal growth inhibition

Jihae Chung, Ignacio Granja, Michael G. Taylor, Giannis Mpourmpakis, John R. Asplin () and Jeffrey D. Rimer ()
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Jihae Chung: University of Houston
Ignacio Granja: Litholink Corporation, Laboratory Corporation of America Holdings
Michael G. Taylor: University of Pittsburgh
Giannis Mpourmpakis: University of Pittsburgh
John R. Asplin: Litholink Corporation, Laboratory Corporation of America Holdings
Jeffrey D. Rimer: University of Houston

Nature, 2016, vol. 536, issue 7617, 446-450

Abstract: Like citrate, the molecule hydroxycitrate is shown to inhibit growth of the crystal that is the principal component of kidney stones, suggesting that hydroxycitrate could be another treatment for kidney stone disease.

Date: 2016
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DOI: 10.1038/nature19062

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