Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying, John M. Asara, Ronald M. Evans, Lewis C. Cantley, Costas A. Lyssiotis () and Alec C. Kimmelman ()
Additional contact information
Cristovão M. Sousa: Dana-Farber Cancer Institute, Harvard Medical School
Douglas E. Biancur: Dana-Farber Cancer Institute, Harvard Medical School
Xiaoxu Wang: Dana-Farber Cancer Institute, Harvard Medical School
Christopher J. Halbrook: University of Michigan Medical School
Mara H. Sherman: Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies
Li Zhang: University of Michigan Medical School
Daniel Kremer: University of Michigan Medical School
Rosa F. Hwang: The University of Texas M.D. Anderson Cancer Center
Agnes K. Witkiewicz: UT Southwestern
Haoqiang Ying: UT MD Anderson Cancer Center
John M. Asara: Beth Israel Deaconess Medical Center and Harvard Medical School
Ronald M. Evans: Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies
Lewis C. Cantley: Meyer Cancer Center, Weill Cornell Medical College
Costas A. Lyssiotis: University of Michigan Medical School
Alec C. Kimmelman: Dana-Farber Cancer Institute, Harvard Medical School

Nature, 2016, vol. 536, issue 7617, 479-483

Abstract: Pancreatic adenocarcinoma cells drive autophagy in tumour microenvironment-associated stellate cells, which release alanine that is used by the cancer cells as a carbon source for a variety of metabolic processes in an otherwise nutrient-poor environment.

Date: 2016
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DOI: 10.1038/nature19084

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