Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

A. J. Venkatakrishnan (), Xavier Deupi, Guillaume Lebon, Franziska M. Heydenreich, Tilman Flock, Tamara Miljus, Santhanam Balaji, Michel Bouvier, Dmitry B. Veprintsev, Christopher G. Tate, Gebhard F. X. Schertler and M. Madan Babu ()
Additional contact information
A. J. Venkatakrishnan: MRC Laboratory of Molecular Biology
Xavier Deupi: Paul Scherrer Institute
Guillaume Lebon: CNRS UMR 5203, Institut de Génomique Fonctionnelle
Franziska M. Heydenreich: Paul Scherrer Institute
Tilman Flock: MRC Laboratory of Molecular Biology
Tamara Miljus: Paul Scherrer Institute
Santhanam Balaji: MRC Laboratory of Molecular Biology
Michel Bouvier: University of Montreal
Dmitry B. Veprintsev: Paul Scherrer Institute
Christopher G. Tate: MRC Laboratory of Molecular Biology
Gebhard F. X. Schertler: Paul Scherrer Institute
M. Madan Babu: MRC Laboratory of Molecular Biology

Nature, 2016, vol. 536, issue 7617, 484-487

Abstract: A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors.

Date: 2016
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DOI: 10.1038/nature19107

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