The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Alexander Küffer, Asvin K. K. Lakkaraju, Amit Mogha, Sarah C. Petersen, Kristina Airich, Cédric Doucerain, Rajlakshmi Marpakwar, Pamela Bakirci, Assunta Senatore, Arnaud Monnard, Carmen Schiavi, Mario Nuvolone, Bianka Grosshans, Simone Hornemann, Frederic Bassilana, Kelly R. Monk and Adriano Aguzzi ()
Additional contact information
Alexander Küffer: Institute of Neuropathology, University of Zurich
Asvin K. K. Lakkaraju: Institute of Neuropathology, University of Zurich
Amit Mogha: Washington University School of Medicine
Sarah C. Petersen: Washington University School of Medicine
Kristina Airich: Institute of Neuropathology, University of Zurich
Cédric Doucerain: Institute of Neuropathology, University of Zurich
Rajlakshmi Marpakwar: Institute of Neuropathology, University of Zurich
Pamela Bakirci: Institute of Neuropathology, University of Zurich
Assunta Senatore: Institute of Neuropathology, University of Zurich
Arnaud Monnard: Institute of Neuropathology, University of Zurich
Carmen Schiavi: Institute of Neuropathology, University of Zurich
Mario Nuvolone: Institute of Neuropathology, University of Zurich
Bianka Grosshans: Novartis Institutes for Biomedical Research
Simone Hornemann: Institute of Neuropathology, University of Zurich
Frederic Bassilana: Novartis Institutes for Biomedical Research
Kelly R. Monk: Washington University School of Medicine
Adriano Aguzzi: Institute of Neuropathology, University of Zurich

Nature, 2016, vol. 536, issue 7617, 464-468

Abstract: The cellular prion protein PrPC promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

Date: 2016
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DOI: 10.1038/nature19312

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